Peer-reviewed publikationer

Peer-reviewed publications

Salasova, A., Monti, G., Andersen, O. M. & Nykjaer, A. (2022). Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease. Molecular Neurodegeneration, 17(1), Artikel 74. https://doi.org/10.1186/s13024-022-00576-2

Ming, J., Lin, Z., Zhao, J., Wan, X., Yang, C., Wu, A. R. & Tabula Microcebus Consortium (2022). FIRM: Flexible integration of single-cell RNA-sequencing data for large-scale multi-tissue cell atlas datasets. Briefings in bioinformatics, 23(5), Artikel bbac167. https://doi.org/10.1093/bib/bbac167

Diniz, C. R. A. F., da Silva, L. A., Domingos, L. B., Sonego, A. B., Moraes, L. R. B. & Joca, S. (2022). Fluoxetine acts concomitantly on dorsal and ventral hippocampus to Trk-dependently modulate the extinction of fear memory. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 113, Artikel 110451. https://doi.org/10.1016/j.pnpbp.2021.110451

Akbey, Ü. & Andreasen, M. (2022). Functional amyloids from bacterial biofilms - structural properties and interaction partners. Chemical Science, 13(22), 6457-6477. https://doi.org/10.1039/d2sc00645f

Nielsen, M. A., Juul-Madsen, K., Stegmayr, J., Gao, C., Mehta, A. Y., Greisen, S. R., Kragstrup, T. W., Hvid, M., Vorup-Jensen, T., Cummings, R. D., Leffler, H. & Deleuran, B. W. (2022). Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB. Frontiers in Immunology, 13, Artikel 915890. https://doi.org/10.3389/fimmu.2022.915890

Xue, J., Thomas, L., Fenton, R. A., Dominguez Rieg, J. A. & Rieg, T. (2022). Generation and characterization of thick ascending limb specific knockout of NHE3 mouse model. The FASEB Journal, 36(S1). https://doi.org/10.1096/fasebj.2022.36.S1.R4942

Cuypers, A., Teuwen, L. A., Bridgeman, V. L., de Rooij, L. P. M. H., Eelen, G., Dewerchin, M., Cantelmo, A. R., Kalucka, J., Bouché, A., Vinckier, S., Carton, A., Manderveld, A., Vermeulen, P. B., Reynolds, A. R. & Carmeliet, P. (2022). Generation of vessel co-option lung metastases mouse models for single-cell isolation of metastases-derived cells and endothelial cells. STAR Protocols, 3(4), Artikel 101691. https://doi.org/10.1016/j.xpro.2022.101691

Debost, J.-C. P. G., Thorsteinsson, E., Trabjerg, B., Benros, M. E., Albiñana, C., Vilhjalmsson, B. J., Børglum, A., Mors, O., Werge, T., Mortensen, P. B., Agerbo, E. & Petersen, L. (2022). Genetic and psychosocial influence on the association between early childhood infections and later psychiatric disorders. Acta Psychiatrica Scandinavica, 146(5), 406-419. https://doi.org/10.1111/acps.13491

Grotzinger, A. D., Mallard, T. T., Akingbuwa, W. A., Ip, H. F., Adams, M. J., Lewis, C. M., McIntosh, A. M., Grove, J., Dalsgaard, S., Lesch, K. P., Strom, N., Meier, S. M., Mattheisen, M., Børglum, A. D., Mors, O., Breen, G., iPSYCH, Tourette Syndrome and Obsessive Compulsive Disorder Working Group of the Psychiatric Genetics Consortium, Bipolar Disorder Working Group of the Psychiatric Genetics Consortium ... Nivard, M. G. (2022). Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis. Nature Genetics, 54(5), 548-559. https://doi.org/10.1038/s41588-022-01057-4

Warrier, V., Zhang, X., Reed, P., Havdahl, A., Moore, T. M., Cliquet, F., Leblond, C. S., Rolland, T., Rosengren, A., Rowitch, D. H., Hurles, M. E., Geschwind, D. H., Børglum, A. D., Robinson, E. B., Grove, J., Martin, H. C., Bourgeron, T., Baron-Cohen, S., EU-AIMS LEAP ... Spectrum 10K and APEX Consortia (2022). Genetic correlates of phenotypic heterogeneity in autism. Nature Genetics, 54(9), 1293-1304. https://doi.org/10.1038/s41588-022-01072-5

Petrillo, F., Chernyakov, D., Esteva Font, C., Poulsen, S. B., Edemir, B. & Fenton, R. A. (2022). Genetic deletion of the nuclear factor of activated T cells 5 in collecting duct principal cells causes nephrogenic diabetes insipidus. FASEB Journal, 36(11), Artikel e22583. https://doi.org/10.1096/fj.202200856R

Eising, E., Mirza-Schreiber, N., de Zeeuw, E. L., Wang, C. A., Truong, D. T., Allegrini, A. G., Shapland, C. Y., Zhu, G., Wigg, K. G., Gerritse, M. L., Molz, B., Alagoz, G., Gialluisi, A., Abbondanza, F., Rimfeld, K., van Donkelaar, M., Liao, Z., Jansen, P. R., Andlauer, T. F. M. ... Fisher, S. E. (2022). Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people. Proceedings of the National Academy of Sciences (PNAS), 119(35), Artikel e2202764119. https://doi.org/10.1073/pnas.2202764119

Karlsson, M., Sjöstedt, E., Oksvold, P., Sivertsson, Å., Huang, J., Álvez, M. B., Arif, M., Li, X., Lin, L., Yu, J., Ma, T., Xu, F., Han, P., Jiang, H., Mardinoglu, A., Zhang, C., von Feilitzen, K., Xu, X., Wang, J. ... Uhlen, M. (2022). Genome-wide annotation of protein-coding genes in pig. BMC Biology, 20, Artikel 25. https://doi.org/10.1186/s12915-022-01229-y

Skotte, L., Fadista, J., Bybjerg-Grauholm, J., Appadurai, V., Hildebrand, M. S., Hansen, T. F., Banasik, K., Grove, J., Albiñana, C., Geller, F., Bjurström, C. F., Vilhjálmsson, B. J., Coleman, M., Damiano, J. A., Burgess, R., Scheffer, I. E., Pedersen, O. B. V., Erikstrup, C., Westergaard, D. ... Feenstra, B. (2022). Genome-wide association study of febrile seizures implicates fever response and neuronal excitability genes. Brain : a journal of neurology, 145(2), 555–568. https://doi.org/10.1093/brain/awab260

Suppli, N. P., Andersen, K. K., Agerbo, E., Rajagopal, V. M., Appadurai, V., Coleman, J. R. I., Breen, G., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Pedersen, C. B., Pedersen, M. G., Thompson, W. K., Munk-Olsen, T., Benros, M. E., Als, T. D., Grove, J., Werge, T., Børglum, A. D., Hougaard, D. M. ... Musliner, K. L. (2022). Genome-wide by Environment Interaction Study of Stressful Life Events and Hospital-Treated Depression in the iPSYCH2012 Sample. Biological Psychiatry: Global Open Science, 2(4), 400-410. https://doi.org/10.1016/j.bpsgos.2021.11.003

Vershkov, D., Yilmaz, A., Yanuka, O., Nielsen, A. L. & Benvenisty, N. (2022). Genome-wide screening for genes involved in the epigenetic basis of fragile X syndrome. Stem Cell Reports, 17(5), 1048-1058. https://doi.org/10.1016/j.stemcr.2022.03.011

Eliasen, A. U., Pedersen, C. E. T., Rasmussen, M. A., Wang, N., Soverini, M., Fritz, A., Stokholm, J., Chawes, B. L., Morin, A., Bork-Jensen, J., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Mortensen, P. B., Hougaard, D. M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Mors, O. ... Bønnelykke, K. (2022). Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB. Journal of Allergy and Clinical Immunology, 150(3), 622-630. https://doi.org/10.1016/j.jaci.2022.03.019

Seeler, S., Moldovan, L.-I., Bertelsen, T., Hager, H., Iversen, L., Johansen, C., Kjems, J. & Sommer Kristensen, L. (2022). Global circRNA expression changes predate clinical and histological improvements of psoriasis patients upon secukinumab treatment. PLoS One, 17(9), Artikel e0275219. https://doi.org/10.1371/journal.pone.0275219

Monti, G., Gomes Moreira, D., Richner, M., Mutsaers, H. A. M., Ferreira, N. & Jan, A. (2022). GLP-1-Receptor Agonists in Neurodegeneration: Neurovascular Unit in the Spotlight. Cells, 11(13), Artikel 2023. https://doi.org/10.3390/cells11132023

Farzadfard, A., König, A., Petersen, S. V., Nielsen, J., Vasili, E., Dominguez-Meijide, A., Buell, A. K., Outeiro, T. F. & Otzen, D. E. (2022). Glycation modulates alpha-synuclein fibrillization kinetics: a sweet spot for inhibition. The Journal of Biological Chemistry, 298(5), Artikel 101848. https://doi.org/10.1016/j.jbc.2022.101848

Skytthe, M. K., Sørensen, A. L., Hennig, D., Sandberg, M. B., Rasmussen, L. M., Højrup, P., Møller, H. J., Skjødt, K., Moestrup, S. K. & Graversen, J. H. (2022). Haptoglobin-related protein in human plasma correlates to haptoglobin concentrations and phenotypes. Scandinavian Journal of Clinical and Laboratory Investigation, 82(6), 461-466. https://doi.org/10.1080/00365513.2022.2122076

Jespersen, A., Yilmaz, Z. & Vilhjálmsson, B. J. (2022). Harnessing the Power of Population Cohorts to Study the Relationship Between Endocrine-Metabolic Disorders and Depression. The American Journal of Psychiatry (Spanish Edition), 179(11), 788-790. https://doi.org/10.1176/appi.ajp.20220798

Dall, L. B., Deleuran, B., Østergaard, L. J., Mardahl, M., Denton, P. W. & Nejsum, P. (2022). Helminth products modulate innate immune recognition of nucleic acids in systemic lupus erythematosus. Lupus, 31(4), 415-423. https://doi.org/10.1177/09612033221080548

Vohwinkel, C. U., Burns, N., Coit, E., Yuan, X., Vladar, E. K., Sul, C., Schmidt, E. P., Carmeliet, P., Stenmark, K., Nozik, E. S., Tuder, R. M. & Eltzschig, H. K. (2022). HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury. JCI Insight, 7(24), Artikel e157855. https://doi.org/10.1172/jci.insight.157855

Yiu, G., Rasmussen, T. K., Tsai, B. L., Diep, V. K., Haddon, D. J., Tsoi, J., Miller, G. D., Comin-Anduix, B., Deleuran, B., Crooks, G. M. & Utz, P. J. (2022). High Interferon Signature Leads to Increased STAT1/3/5 Phosphorylation in PBMCs From SLE Patients by Single Cell Mass Cytometry. Frontiers in Immunology, 13, Artikel 833636. https://doi.org/10.3389/fimmu.2022.833636

Laursen, T. L., Bossen, L., Pihl, R., Troldborg, A., Sandahl, T. D., Hansen, A. G., Folserass, T., Vesterhus, M., Gronbaek, H. & Thiel, S. (2022). Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4 (ITIH4) in Autoimmune Cholestatic Liver Diseases. Journal of clinical and translational hepatology, 10(5), 796–802. https://doi.org/10.14218/JCTH.2021.00515

Watson, H. R., Duong, V., Ly, S., Mandron, M., Siqueira, A. M. & Ribeiro, G. S. (2022). Household clustering supports a novel chemoprophylaxis trial design for a mosquito-borne viral disease. International Journal of Infectious Diseases, 122, 169-173. https://doi.org/10.1016/j.ijid.2022.05.020

Cen, H. H., Hussein, B., Botezelli, J. D., Wang, S., Zhang, J. A., Noursadeghi, N., Jessen, N., Rodrigues, B., Timmons, J. A. & Johnson, J. D. (2022). Human and mouse muscle transcriptomic analyses identify insulin receptor mRNA downregulation in hyperinsulinemia-associated insulin resistance. The FASEB Journal, 36(1), Artikel e22088. https://doi.org/10.1096/fj.202100497RR

Peng, R., Wang, C. K., Wang-Kan, X., Idorn, M., Kjær, M., Zhou, F. Y., Fiil, B. K., Timmermann, F., Orozco, S. L., McCarthy, J., Leung, C. S., Lu, X., Bagola, K., Rehwinkel, J., Oberst, A., Maelfait, J., Paludan, S. R. & Gyrd-Hansen, M. (2022). Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1. EMBO Reports, 23(12), Artikel e55839. https://doi.org/10.15252/embr.202255839

Brent, M. B., Emmanuel, T., Simonsen, U., Brüel, A. & Thomsen, J. S. (2022). Hypobaric hypoxia deteriorates bone mass and strength in mice. Bone, 154, Artikel 116203. https://doi.org/10.1016/j.bone.2021.116203

Egstrand, S., Mace, M. L., Morevati, M., Nordholm, A., Engelholm, L. H., Thomsen, J. S., Brüel, A., Naveh-Many, T., Guo, Y., Olgaard, K. & Lewin, E. (2022). Hypomorphic expression of parathyroid Bmal1 disrupts the internal parathyroid circadian clock and increases parathyroid cell proliferation in response to uremia. Kidney International, 101(6), 1232-1250. https://doi.org/10.1016/j.kint.2022.02.018

Maccio, U., Mihic, A., Lenggenhager, D., Kolm, I., Mittmann, C., Heikenwälder, M., Lorentzen, A. & Mihic-Probst, D. (2022). Hypoxia and Ezrin Expression in Primary Melanoma Have High Prognostic Relevance. International Journal of Molecular Sciences , 23(18), Artikel 10745. https://doi.org/10.3390/ijms231810745

Taha, Z., Arulanandam, R., Maznyi, G., Godbout, E., Carter-Timofte, M. E., Kurmasheva, N., Reinert, L. S., Chen, A., Crupi, M. J. F., Boulton, S., Laroche, G., Phan, A., Rezaei, R., Alluqmani, N., Jirovec, A., Acal, A., Brown, E. E. F., Singaravelu, R., Petryk, J. ... Diallo, J.-S. (2022). Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen. Molecular Therapy, 30(9), 2998-3016. https://doi.org/10.1016/j.ymthe.2022.04.025

Bastrup, J. A., Aalkjær, C. & Jepps, T. A. (2022). Identification of novel proteins and mechanistic pathways associated with early-onset hypertension by deep proteomic mapping of resistance arteries. Journal of Biological Chemistry, 298(1), Artikel 101512. https://doi.org/10.1016/j.jbc.2021.101512

Mattheisen, M., Grove, J., Als, T. D., Martin, J., Voloudakis, G., Meier, S., Demontis, D., Bendl, J., Walters, R., Carey, C. E., Rosengren, A., Strom, N. I., Hauberg, M. E., Zeng, B., Hoffman, G., Zhang, W., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Agerbo, E. ... Børglum, A. D. (2022). Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups. Nature Genetics, 54(10), 1470-1478. https://doi.org/10.1038/s41588-022-01171-3

GSRD Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2022). Identifying the Common Genetic Basis of Antidepressant Response. Biological Psychiatry: Global Open Science, 2(2), 115-126. https://doi.org/10.1016/j.bpsgos.2021.07.008

Griffante, G., Hewelt-Belka, W., Albano, C., Gugliesi, F., Pasquero, S., Castillo Pacheco, S. F., Bajetto, G., Porporato, P. E., Mina, E., Vallino, M., Krapp, C., Jakobsen, M. R., Purdy, J., von Einem, J., Landolfo, S., Dell'Oste, V. & Biolatti, M. (2022). IFI16 Impacts Metabolic Reprogramming during Human Cytomegalovirus Infection. mBio, 13(3), e0043522. https://doi.org/10.1128/mbio.00435-22

Hussmann, D., Starnawska, A., Kristensen, L., Daugaard, I., Thomsen, A., Kjeldsen, T., Hansen, C. S., Bybjerg-Grauholm, J., Dalsgaard Johansen, K., Ludvigsen, M., Kristensen, T., Larsen, T. S., Møller, M. B., Nyvold, C. G., Hansen, L. L. & Wojdacz, T. K. (2022). IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load. Haematologica, 107(4), 877-886. https://doi.org/10.3324/haematol.2021.278477

Holme, S. A. N., Vorup-Jensen, T. & Juul-Madsen, K. (2022). Immunoassay for detection of oligomeric proteins. Journal of Immunological Methods, 505, Artikel 113277. https://doi.org/10.1016/j.jim.2022.113277

Mikkelsen, R. R., Hundahl, M. P., Torp, C. K., Rodríguez-Carrio, J., Kjolby, M., Bruun, J. M. & Kragstrup, T. W. (2022). Immunomodulatory and immunosuppressive therapies in cardiovascular disease and type 2 diabetes mellitus: A bedside-to-bench approach. European Journal of Pharmacology, 925, Artikel 174998. https://doi.org/10.1016/j.ejphar.2022.174998

Klæstrup, I. H., Pedersen, M. K. J., Holm, K. L., Alstrup, A. K. O., Romero-Ramos, M., Borghammer, P. & Van Den Berge, N. (2022). Impact of aging on animal models of Parkinson´s disease. Frontiers in Aging Neuroscience, 14, Artikel 909273. https://doi.org/10.3389/fnagi.2022.909273

Schepelmann, M., Ranieri, M., Lopez-Fernandez, I., Webberley, T. S., Brennan, S. C., Yarova, P. L., Graca, J., Hanif, U.-K., Müller, C., Manhardt, T., Salzmann, M., Quasnichka, H., Price, S. A., Ward, D. T., Gilbert, T., Matchkov, V. V., Fenton, R. A., Herberger, A., Hwong, J. ... Riccardi, D. (2022). Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells. Journal of the American Society of Nephrology : JASN, 33(7), 1323-1340. https://doi.org/10.1681/ASN.2021040585

Jönsson, Å. L. M., Hernando, N., Knöpfel, T., Mogensen, S., Bendstrup, E., Hilberg, O., Christensen, J. H., Simonsen, U. & Wagner, C. A. (2022). Impaired phosphate transport in SLC34A2 variants in patients with pulmonary alveolar microlithiasis. Human Genomics, 16(1), Artikel 13. https://doi.org/10.1186/s40246-022-00387-y

Gohr, M., Jakobsen, I. M., Helmig, R. B., Stengaard-Pedersen, K., Laurberg, T. B. & Troldborg, A. (2022). Improved pregnancy outcomes in systemic lupus erythematosus: A retrospective study of pregnancies from a single centre in Denmark from 2010–2020 compared with the period 1990–2010. Lupus, 31(10), 1202-1210. https://doi.org/10.1177/09612033221107538

Moellgaard, M. H., Lund, I. C. B., Becher, N., Skytte, A.-B., Andreasen, L., Srebniak, M. I. & Vogel, I. (2022). Incidental finding of maternal malignancy in an unusual non-invasive prenatal test and a review of similar cases. Clinical Case Reports, 10(10), Artikel e6280. https://doi.org/10.1002/ccr3.6280

Jepsen, M. R., Østergaard, J. A., Conover, C. A., Wogensen, L., Birn, H., Krag, S. P., Fenton, R. A. & Oxvig, C. (2022). Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy. Metabolism: Clinical and Experimental, 132, Artikel 155218. https://doi.org/10.1016/j.metabol.2022.155218

Fonager, S. V., Winther, G., Wittenborn, T. R., Jensen, L., Fahlquist-Hagert, C., Hansen, L. A., Füchtbauer, E.-M., Romero-Ramos, M. & Degn, S. E. (2022). Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring. Journal of Neuroimmunology, 370, Artikel 577927. https://doi.org/10.1016/j.jneuroim.2022.577927

Pedersen, J. G., Sokac, M., Sørensen, B. S., Luczak, A. A., Aggerholm-Pedersen, N., Birkbak, N. J., Øllegaard, T. H. & Jakobsen, M. R. (2022). Increased Soluble PD-1 Predicts Response to Nivolumab plus Ipilimumab in Melanoma. Cancers, 14(14), Artikel 3342. https://doi.org/10.3390/cancers14143342

Kilian, M., Husby, S., Andersen, J., Moldoveanu, Z., Skov Sørensen, U. B., Reinholdt, J. & Tettelin, H. (2022). Induction of Susceptibility to Disseminated Infection with IgA1 Protease-Producing Encapsulated Pathogens Streptococcus pneumoniae, Haemophilus influenzae Type b, and Neisseria meningitidis. mBio, 13(3). https://doi.org/10.1128/mbio.00550-22

Taryma-Lesniak, O., Kjeldsen, T. E., Hansen, L. L. & Wojdacz, T. K. (2022). Influence of Unequal Amplification of Methylated and Non-Methylated Template on Performance of Pyrosequencing. Genes, 13(8), Artikel 1418. https://doi.org/10.3390/genes13081418

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