Which traces do liver metastases leave behind?
Colorectal cancer can cause liver metastases. Joanna Maria Kalucka from Department of Biomedicine has received ten million DKK from the Novo Nordisk Foundation to study the molecular signature of liver cancer metastases.
Colorectal cancer is one of the most common forms of cancer, and at the same time, it is a highly metastatic type of tumour that can spread for instance to the liver. . Assistant Professor Joanna Maria Kalucka from the Department of Biomedicine has received ten million DKK from the Novo Nordisk Foundation to carry out research on colorectal cancer liver metastases.
Together with Dr. Lena-Christin Conradi from the University of Göttingen, Joanna Maria Kalucka will study two forms of metastasis. First one, is a form in which cancer cells induce the formation of the new blood vessels and thus support tumour growth. Second, a more invasive type of metastases, where the cancer cells hijack the existing patient’s blood vessels. The two female researchers aim to identify the molecular signatures for liver cancer metastases, among other things by investigating tumours at cellular level and in blood samples from patients. The hope is to improve patients’ prognosis by becoming better at targeting treatment at the given type of metastasis.