Biomedicine Seminar

Lecturer: Professor Antoine de Morree: "Regulation of stem cell quiescence in the maintenance of tissue integrity"

Info about event

Time

Wednesday 2 February 2022,  at 12:00 - 13:00

Location

Ll. Anat. aud. 1231-424

Organizer

Biomedicine

Abstract

The ability of tissues to repair themselves after an injury is due to the presence of populations of rare stem cells in those tissues. In skeletal muscle, muscle stem cells (MuSCs) exist in a quiescent state, a state of prolonged reversible cell cycle exit, in reserve to be called upon if an injury occurs. When muscle is injured, the MuSCs activate to enter the cell cycle, proliferate, and make new muscle. The quiescent state is actively maintained and essential for long-term maintenance of the stem cell pool. The mechanisms that enable MuSCs to maintain or break the quiescent state are poorly understood. A major challenge has been the lack of tools to analyze quiescent stem cells in vivo, in their native environment. We used cell-specific labeling of RNA to investigate the transcriptome of quiescent MuSCs in vivo. These new approaches revealed a discordance between RNA and protein levels, indicating the importance of post-transcriptional mechanisms for the regulation of the quiescent state. Understanding how these mechanisms guide stem cell function during homeostasis and regeneration has important implications for regenerative medicine.

Bio: Antoine de Morree is tenure-track Assistant Professor of Biomedicine at Aarhus University.  His main research interest is to understand how stem cells regenerate tissue with the goal of improving tissue regeneration in aging and disease. Antoine de Morree received his PhD from Leiden University, The Netherlands in 2011, and completed his postdoctoral training at Stanford University in 2018. His work has led to major awards, including the 2015 Development Grant from the Muscular Dystrophy Association and a leadership award from Stanford University.

Venue:

The seminar will be held at 12:00 pm in 1231-424  Lille Anatomisk Auditorium

 And at Zoom: https://aarhusuniversity.zoom.us/j/69390172000

The talk is 45 minutes followed by 15 minutes of discussion, for a total of 1 hr.

Sign-up: It is possible to sign-up for a free sandwich if you follow this link: Biomedicine Seminar 2 February 2022 (au.dk)

 Please note the deadline for sandwich sign-up is Monday 31st January 2022 

 

The Biomedicine Organising Committee
Mikkel Vendelbo
Line Reinert
Søren Egedal Degn 
Martin Kristian Thomsen