Biomedicine Seminar

Title: ”Decoding Neuronal Vulnerability: Integrating Neurodevelopmental Influences and Molecular Mechanisms in Neurodegeneration”

Abstract:
Neuronal vulnerability in neurodegeneration is a complex phenomenon shaped by both intrinsic neuronal properties and interactions with surrounding microglia. This project aims to unravel the molecular logic behind selective neuronal susceptibility, with a focus on the hypothalamus, a critical brain region responsible for homeostasis. By leveraging single-cell and spatial transcriptomics, we will construct in silico gene regulatory networks (GRNs) to identify molecular drivers across development and neurodegenerative stages. These findings will be validated through in vitro CRISPR-RNP screening, live imaging, and single-molecule fISH, followed by in vivo studies. Understanding these mechanisms is crucial for developing targeted therapeutic strategies to mitigate neurodegenerative diseases.

Venue:
The seminar will be held at 12:00-13:00 pm in 1231-424, Lille Anatomisk Auditorium.

Or via Zoom, for those of you who cannot attend in person: https://aarhusuniversity.zoom.us/j/62303995584 

The talk is 45 minutes followed by 15 minutes of discussion, for a total of 1 hr.

Sign-up:
It is possible to sign-up for a free sandwich if you follow this link: Sign up                
Please note the deadline for sandwich sign-up is Monday September 2^nd.

Biomedicine seminar organizing committee
Mikkel Vendelbo
Line Reinert
Søren Egedal Degn 
Martin Kristian Thomsen