Biomedicine Seminar

Lecturer: Rodrigo Grassi-Oliveira - Title: Cross-Species Insights into Prefrontal Cortex-Derived Extracellular Vesicles and Substance Use Disorder

Oplysninger om arrangementet

Tidspunkt

Onsdag 2. april 2025,  kl. 12:00 - 13:00

Sted

Lille Ana (1231-424)

Abstract: 
Substance use disorder (SUD) disrupts neuroplasticity and promotes neuroinflammation, potentially mediated by extracellular vesicles (EVs). EVs encapsulate molecular cargo reflective of their cells of origin, providing insight into SUD-induced brain changes.  We investigated prefrontal cortex-derived EVs from postmortem human brains (Brodmann’s area 9, BA9) and rodent models of chronic morphine exposure, using multiomics profiling (proteomics, lipidomics, RNA-seq, Nanostring) to identify molecular alterations. Primary neuron cultures of mice were treated with brain-derived EVs (BDEs) to assess their impact on gene expression and glial activity.